Therapeutic Focus Areas For a Clinical/Statistical SAS Programmer

First Question for A Clinical Programmer Is — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — →Which Therapeutic Areas Did You Worked ?

Short answer is Cardiology, Immunology, Infectious Diseases & Vaccines, Metabolism And Endocrinology, Neuroscience, Oncology, Respiratory Etc.

I will give a range of therapeutic areas examples but mostly will emphasize on Cell and Gene.

CELL & GENE THERAPY

A. CELL THERAPY : Cell therapy aims to treat diseases by restoring or altering certain sets of cells or by using cells to carry a therapy through the body. With cell therapy, cells are cultivated or modified outside the body before being injected into the patient. The cells may originate from the patient (autologous cells) or a donor (allogeneic cells). Chimeric Antigen Receptor (CAR) T-cell therapies for acute lymphoblastic leukemia (ALL), autoimmune disease like MS.
Examples of Cellular Therapy:
1. Kymriah (tisagenlecleucel) : Kymriah is a CD19-directed CAR-T therapy used for the treatment of specific leukemias and lymphomas
2. Yescarta (axicabtagene ciloleucel) : Yescarta is a CD19-directed CAR-T therapy used for the treatment of specific B-cell lymphomas

B. GENE THERAPY: Gene therapy aims to treat diseases by replacing, inactivating or introducing genes into cells -either inside the body (in-vivo) or outside of the body (ex-vivo).
Examples of Gene Therapy
1. Zolgensma (onasemnogene abeparvovec-xioi): Zolgensma is recombinant AAV9-based gene therapy designed to deliver a copy of the gene encoding the human survival motor neuron (SMN) protein for the treatment of spinal muscular atrophy (SMA) that is administered via IV infusion.
2. Luxturna (voretigene neparvovec-rzyl): Luxturna is an AAV gene therapy for subretinal injection. Luxturna delivers a normal gene encoding the human retinal pigment epithelial 65 kDa protein (RPE65) to cells of the retina in persons with reduced or absent levels of biologically active RPE65.
3. Misfolding proteins bring caution for gene therapies for haemophilia
4. In-vivo gene editing using a system called CRISPR for treating sickle cell disease and a closely related disorder, called beta thalassemia

CARDIOLOGY

CARDIOVASCULAR | HEART FAILURE | QT STUDIES | TRADITIONAL CHINESE MEDICINE — CORONARY ARTERY DISEASE-ANGINA

GASTROENTEROLOGY

CDAD | CROHN’S DISEASE

IMMUNOLOGY

AUTOIMMUNE/RHEUMATOLOGY

PSORIASIS | RHEUMATOID ARTHRITIS | PSORIASIS | RHEUMATOID ARTHRITIS | INFLAMMATORY BOWEL DISEASE (IBD) | SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) | NONALCOHOLIC STEATOHEPATITIS (NASH)

INFECTIOUS DISEASES & VACCINES

COVID-19 | EBOLA | HEPATITIS C | HIV | INFLUENZA | MALARIA | TUBERCULOSIS | VIROLOGY

METABOLISM AND ENDOCRINOLOGY

ACUTE KIDNEY INJURY | DIABETES |DIABETES TYPE 1 — EXERCISE AND NUTRITION | DIABETES TYPE 1 — PEDIATRICS AND DEVICES | DIABETES TYPE 1 — SCREENING, STAGING AND MONITORING OF PRE-CLINICAL TYPE 1 DIABETES | DIABETIC KIDNEY DISEASE | DYSLIPIDEMIA | KIDNEY TRANSPLANT | POLYCYSTIC KIDNEY DISEASE

NEUROSCIENCE/NEUROLOGY/PSYCHIATRY/CNS

ALZHEIMER’S | HUNTINGTON’S DISEASE | MULTIPLE SCLEROSIS | PARKINSON’S DISEASE | TRAUMATIC BRAIN INJURY | MAJOR DEPRESSIVE DISORDER | POST TRAUMATIC STRESS DISORDER | SCHIZOPHRENIA | RARE EPILEPSIES

ONCOLOGY AND HEMATOLOGY

SOLID TUMORS | HEMATOLOGY | HEMATOLOGIC MALIGNANCIES | ACUTE MYELOID LEUKEMIA | CHRONIC MYELOMONOCYTIC LEUKEMIA | MULTIPLE MYELOMA | BREAST CANCER | COLORECTAL CANCERS | LUNG CANCER | PANCREATIC CANCER | PROSTATE CANCER

Solid Tumors

All solid tumors
Brain tumors, Bladder cancer, Breast cancer, Cervical cancer, Colorectal cancer, Endometrial cancer, Gastric cancer, Head and neck cancer, Liver cancer, Lung cancer (NSCLC), Melanoma, Neuroendocrine tumors, Ovarian cancer, Pancreatic cancer, Prostate cancer, Renal cancer
Sarcoma

Hemato-Oncology

All hemato-oncology, Acute lymphoblastic leukemia (ALL), Acute myeloid leukemia (AML), Chronic lymphocytic leukemia (CLL), Chronic myeloid leukemia (CML), Lymphoma, Multiple myeloma, Myelofibrosis, Myelodysplastic syndromes, Graft versus host disease, Veno-occlusive disease

Hematology

Anemia, Anticoagulant Reversal, Autoimmune Hemolytic Anemia, Thrombocythaemia, Graft Versus Host Disease,
Hyperbilirubinemia (Genetic), Neutropenia, Paroxysmal Nocturnal, Sickle Cell Anemia, Thrombotic Thrombocytopenic Purpura

RESPIRATORY/RESPIROLOGY

ASTHMA
COPD
COVID-19
Urticaria
Rhinitis, Seasonal/Perennial
Birch/Cat/Grass/Food/Dust Mite Allergy

WOMEN’S HEALTH/OBSTETRICS/GYNECOLOGY

Polycystic Ovarian Syndrome (PCOS), Osteoporosis, Premature Labor (Tocolysis), Vulvovaginal Candidiasis, Overactive Bladder (OAB), Vasomotor Symptoms of Menopause (Hot Flashes), Endometriosis, Leiomyoma (Uterine Fibroids), HPV related Cervical and Genital Dysplasia, Cervical Intraepithelial Neoplasia (CIN), Women Infertility, Menopausal Disorders, Pregnancy complications, Preeclampsia, Premature Ovarian Failure, Atrophic Vaginitis